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The vitamin D receptor (VDR) is a nuclear transcriptional regulator that activates by binding to 1a,25-dihydroxycholecalciferol (1a,25(OH)2D), known as calcitriol, which forms a heterodimer with the retinoid X receptor (RXR). Calcitriol signalling plays a role in a variety of biological effects, including the metabolism of calcium and phosphorous, parathormone release, cell expansion and control of adaptive and innate immunity.
A T > C base modification in the promoter region of the VDR variant rs11568820 eliminates the binding site for transcription factor Cdx2 upstream of exon 1e and leads to the production of a less sized protein with reduced transcriptional activity. The F allele is learn the facts here now present in high frequency among Asians and Europeans and is not found in a high frequency among Africans living in Sub-Saharan Africa.
The findings of this study advance our understanding of the role VDR gene polymorphisms might influence the response to dietary supplementation with calcium calcitriol. People who carry the TaqI and FF genotypes of the FokI polymorphisms have higher transcriptional activation and are associated with greater calcium absorption, increased bone mineral density, and a reduced chance of fractures. Further research using more homogeneous designs is required to increase our understanding of how these genetic variations affect vitamin D supplementation and its clinical significance.